Structure of PDB 1wx4 Chain A Binding Site BS03

Receptor Information
>1wx4 Chain A (length=273) Species: 79261 (Streptomyces castaneoglobisporus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVRKNQATLTADEKRRFVAAVLELKRSGRYDEFVRTHNEFIMSDTDSGER
TGHRSPSFLPWHRRFLLDFEQALQSVDSSVTLPYWDWSADRTVRASLWAP
DFLGGTGRSTDGRVMDGPFAASTGNWPINVRVDSRTYLRRSLGGSVAELP
TRAEVESVLAISAYDLPPYNSASEGFRNHLEGWRGVNLHNRVHVWVGGQM
ATGVSPNDPVFWLHHAYVDKLWAEWQRRHPDSAYVPTGGTPDVVDLNETM
KPWNTVRPADLLDHTAYYTFDAL
Ligand information
Ligand IDPER
InChIInChI=1S/O2/c1-2/q-2
InChIKeyANAIPYUSIMHBEL-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[O-][O-]
FormulaO2
NamePEROXIDE ION
ChEMBL
DrugBank
ZINC
PDB chain1wx4 Chain A Residue 409 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1wx4 Crystallographic Evidence That the Dinuclear Copper Center of Tyrosinase Is Flexible during Catalysis
Resolution1.5 Å
Binding residue
(original residue number in PDB)		H38 H54 H190 H194 H216
Binding residue
(residue number reindexed from 1)		H37 H53 H189 H193 H215
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.18.1: tyrosinase.
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:1wx4, PDBe:1wx4, PDBj:1wx4
PDBsum1wx4
PubMed16436386
UniProtQ83WS2

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