Structure of PDB 1wlj Chain A Binding Site BS03

Receptor Information
>1wlj Chain A (length=168) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EVVAMDCEMVGLGPHRESGLARCSLVNVHGAVLYDKFIRPEGEITDYRTR
VSGVTPQHMVGATPFAVARLEILQLLKGKLVVGHDLKHDFQALKEDMSGY
TIYDTSTDRLLWREAKLVSLRVLSERLLHKSIQNSLLGHSSVEDARATME
LYQISQRIRARRGLPRLA
Ligand information
Ligand IDU5P
InChIInChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKeyDJJCXFVJDGTHFX-XVFCMESISA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C1NC(=O)N(C=C1)C2OC(C(O)C2O)COP(=O)(O)O
CACTVS 3.341O[CH]1[CH](O)[CH](O[CH]1CO[P](O)(O)=O)N2C=CC(=O)NC2=O
OpenEye OEToolkits 1.5.0C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)O
OpenEye OEToolkits 1.5.0C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)O)O)O
CACTVS 3.341O[C@H]1[C@@H](O)[C@@H](O[C@@H]1CO[P](O)(O)=O)N2C=CC(=O)NC2=O
FormulaC9 H13 N2 O9 P
NameURIDINE-5'-MONOPHOSPHATE
ChEMBLCHEMBL214393
DrugBankDB03685
ZINCZINC000002123545
PDB chain1wlj Chain A Residue 300 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1wlj Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease
Resolution1.9 Å
Binding residue
(original residue number in PDB)		D11 E13 M14 R53 S57 H149
Binding residue
(residue number reindexed from 1)		D6 E8 M9 R48 S52 H139
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.13.1: exoribonuclease II.
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004527 exonuclease activity
GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity
GO:0008859 exoribonuclease II activity
GO:0030619 U1 snRNA binding
GO:0030620 U2 snRNA binding
GO:0034511 U3 snoRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006308 DNA catabolic process
GO:0006364 rRNA processing
GO:0006401 RNA catabolic process
GO:0009615 response to virus
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response
GO:0051607 defense response to virus
Cellular Component
GO:0000932 P-body
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0015030 Cajal body
GO:0016605 PML body

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1wlj, PDBe:1wlj, PDBj:1wlj
PDBsum1wlj
PubMed15527770
UniProtQ96AZ6|ISG20_HUMAN Interferon-stimulated gene 20 kDa protein (Gene Name=ISG20)

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