Structure of PDB 1w6l Chain A Binding Site BS03

Receptor Information

>1w6l Chain A (length=503) Species: 1423 (Bacillus subtilis)

TLEKFVDALPIPDTLKPVQQSKEKTYYEVTMEECTHQLHRDLPPTRLWGY
NGLFPGPTIEVKRNENVYVKWMNNLPSTHFLPIDHTIHEEPEVKTVVHLH
GGVTPDDSDGYPEAWFSKDFEQTGPYFKREVYHYPNQQRGAILWYHDHAM
ALTRLNVYAGLVGAYIIHDPKEKRLKLPSDEYDVPLLITDRTINEDGSLF
YPSAPENPSPSLPNPSIVPAFCGETILVNGKVWPYLEVEPRKYRFRVINA
SNTRTYNLSLDNGGDFIQIGSDGGLLPRSVKLNSFSLAPAERYDIIIDFT
AYEGESIILANSAGCGGDVNPETDANIMQFRVTKPLAQKDESRKPKYLAS
YPSVQHERIQNIRTLKLAGTQDEYGRPVLLLNNKRWHDPVTETPKVGTTE
IWSIINPTRGTHPIHLHLVSFRVLDRRPFDIARYQESGELSYTGPAVPPP
PSEKGWKDTIQAHAGEVLRIAATFGPYSGRYVWHCHILEHEDYDMMRPMD
ITD

Ligand information

• Ligand ID: CU
• InChI: InChI=1S/Cu/q+2
• InChIKey: JPVYNHNXODAKFH-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Cu+2]
  CACTVS 3.341: [Cu++]
• Formula: Cu
• Name: COPPER (II) ION
• DrugBank: DB14552
• PDB chain: 1w6l Chain A Residue 1513

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1w6l Dioxygen Reduction by Multi-Copper Oxidases; a Structural Perspective.
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): H155 H424 H491
• Binding residue (residue number reindexed from 1): H148 H417 H484
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.10.3.2: laccase.
  1.3.3.5: bilirubin oxidase.

Gene Ontology

Molecular Function

• GO:0005507 copper ion binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0030435 sporulation resulting in formation of a cellular spore

Cellular Component

• GO:0030288 outer membrane-bounded periplasmic space

External links

• PDB: RCSB:1w6l, PDBe:1w6l, PDBj:1w6l
• PDBsum: 1w6l
• PubMed: 16234932
• UniProt: P07788|COTA_BACSU Laccase (Gene Name=cotA)