Structure of PDB 1u1j Chain A Binding Site BS03

Receptor Information
>1u1j Chain A (length=746) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASHIVGYPRMGPKRELKFALESFWDGKSTAEDLQKVSADLRSSIWKQMSA
AGTKFIPSNTFAHYDQVLDTTAMLGAVPPRYGYTGGEIGLDVYFSMARGN
ASVPAMEMTKWFDTNYHYIVPELGPEVNFSYASHKAVNEYKEAKALGVDT
VPVLVGPVSYLLLSKAAKGVDKSFELLSLLPKILPIYKEVITELKAAGAT
WIQLDEPVLVMDLEGQKLQAFTGAYAELESTLSGLNVLVETYFADIPAEA
YKTLTSLKGVTAFGFDLVRGTKTLDLVKAGFPEGKYLFAGVVDGRNIWAN
DFAASLSTLQALEGIVGKDKLVVSTSCSLLHTAVDLINETKLDDEIKSWM
AFAAQKVVEVNALAKALAGQKDEALFSANAAALASRRSSPRVTNEGVQKA
AAALKGSDHRRATNVSARLDAQQKKLNLPILPTTTIGSFPQTVELREDYV
KAIKEEIKKVVDLQEELDIDVLVHGEPERNDMVEYFGEQLSGFAFTANGW
VQSYGSRCVKPPVIYGDVSRPKAMTVFWSAMAQSMTSRPMKGMLTGPVTI
LNWSFVRNDQPRHETCYQIALAIKDEVEDLEKGGIGVIQIDEAALREGLP
LRKSEHAFYLDWAVHSFRITNCGVQDSTQIHTHMCYSHFNDIIHSIIDMD
ADVITIENSRSDEKLLSVFREGVKYGAGIGPGVYDIHSPRIPSSEEIADR
VNKMLAVLEQNILWVNPDCGLKTRKYTEVKPALKNMVDAAKLIRSQ
Ligand information
Ligand IDMET
InChIInChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChIKeyFFEARJCKVFRZRR-BYPYZUCNSA-N
SMILES
SoftwareSMILES
CACTVS 3.341CSCC[CH](N)C(O)=O
OpenEye OEToolkits 1.5.0CSCCC(C(=O)O)N
CACTVS 3.341CSCC[C@H](N)C(O)=O
OpenEye OEToolkits 1.5.0CSCC[C@@H](C(=O)O)N
ACDLabs 10.04O=C(O)C(N)CCSC
FormulaC5 H11 N O2 S
NameMETHIONINE
ChEMBLCHEMBL42336
DrugBankDB00134
ZINCZINC000001532529
PDB chain1u1j Chain A Residue 772 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1u1j Crystal structures of cobalamin-independent methionine synthase complexed with zinc, homocysteine, and methyltetrahydrofolate
Resolution2.4 Å
Binding residue
(original residue number in PDB)		I437 G438 S439 E490 M496 M557 C649 G734
Binding residue
(residue number reindexed from 1)		I436 G437 S438 E476 M482 M543 C635 G720
Annotation score5
Enzymatic activity
Enzyme Commision number 2.1.1.14: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase.
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008172 S-methyltransferase activity
GO:0008270 zinc ion binding
GO:0008705 methionine synthase activity
GO:0046872 metal ion binding
Biological Process
GO:0006346 DNA methylation-dependent heterochromatin formation
GO:0008652 amino acid biosynthetic process
GO:0009086 methionine biosynthetic process
GO:0010043 response to zinc ion
GO:0032259 methylation
GO:0071266 'de novo' L-methionine biosynthetic process
Cellular Component
GO:0000325 plant-type vacuole
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009506 plasmodesma
GO:0009507 chloroplast
GO:0009570 chloroplast stroma
GO:0048046 apoplast

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1u1j, PDBe:1u1j, PDBj:1u1j
PDBsum1u1j
PubMed15326182
UniProtO50008|METE1_ARATH 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 (Gene Name=MS1)

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