Structure of PDB 1sx8 Chain A Binding Site BS03
Receptor Information
>1sx8 Chain A (length=241) Species:
562
(Escherichia coli) [
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SLRSDLINALYDENQKYDVCGIISAEGKIYPLGSDTKVLSTIFELFSRPI
INKIAEKHGYIVEEPKQQNHYPDFTLYKPSEPNKKIAIDIATTYTNKENE
KIKFTLGGYTSFIRNNTKNIVYPFDQYIAHWIIGYVYTRVKSSLKTYNIN
ELNEIPKPYKGVKVFLQDKWVIAGDLAGSGNTTNIGSIHAHYKDFVEGKG
IFDSEDEFLDYWRNYERTSQLRNDKYNNISEYRNWIYRGRK
Ligand information
Ligand ID
MN
InChI
InChI=1S/Mn/q+2
InChIKey
WAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
Software
SMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Mn+2]
CACTVS 3.341
[Mn++]
Formula
Mn
Name
MANGANESE (II) ION
ChEMBL
DrugBank
DB06757
ZINC
PDB chain
1sx8 Chain A Residue 246 [
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Receptor-Ligand Complex Structure
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PDB
1sx8
DNA Cleavage by EcoRV Endonuclease: Two Metal Ions in Three Metal Ion Binding Sites
Resolution
2.15 Å
Binding residue
(original residue number in PDB)
D74 D90
Binding residue
(residue number reindexed from 1)
D73 D89
Annotation score
4
Enzymatic activity
Enzyme Commision number
3.1.21.4
: type II site-specific deoxyribonuclease.
Gene Ontology
Molecular Function
GO:0003677
DNA binding
GO:0004519
endonuclease activity
GO:0009036
type II site-specific deoxyribonuclease activity
GO:0046872
metal ion binding
Biological Process
GO:0009307
DNA restriction-modification system
View graph for
Molecular Function
View graph for
Biological Process
External links
PDB
RCSB:1sx8
,
PDBe:1sx8
,
PDBj:1sx8
PDBsum
1sx8
PubMed
15170321
UniProt
P04390
|T2E5_ECOLX Type II restriction enzyme EcoRV (Gene Name=ecoRVR)
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