Structure of PDB 1slm Chain A Binding Site BS03

Receptor Information

>1slm Chain A (length=226) Species: 9606 (Homo sapiens)

LVQKYLENYYDLKKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPR
CGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVW
EEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGI
NGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYH
SLTDLTRFRLSQDDINGIQSLYGPPP

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 1slm Chain A Residue 259

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1slm Stromelysin-1: three-dimensional structure of the inhibited catalytic domain and of the C-truncated proenzyme.
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): D158 G159 G161 V163 D181 E184
• Binding residue (residue number reindexed from 1): D134 G135 G137 V139 D157 E160
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): H201 E202 H205 H211
• Catalytic site (residue number reindexed from 1): H177 E178 H181 H187
• Enzyme Commision number: 3.4.24.17: stromelysin 1.

Gene Ontology

Molecular Function

• GO:0004222 metalloendopeptidase activity
• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0031012 extracellular matrix

External links

• PDB: RCSB:1slm, PDBe:1slm, PDBj:1slm
• PDBsum: 1slm
• PubMed: 8535233
• UniProt: P08254|MMP3_HUMAN Stromelysin-1 (Gene Name=MMP3)