Structure of PDB 1sgl Chain A Binding Site BS03

Receptor Information

>1sgl Chain A (length=206) Species: 282652 (Trichosanthes lepiniana)

EFDYFILALQWAGTSCRSGGACCPYNGCCKADSPTQFTIHGLRPEYSGGE
RPSCCTGGSFDPDEIMPFFGKLVEYWPTYRCALEQSCNNRKEILWGQQYE
KHGTCASPVIKGEWNYFKKTLKLFMKYNVDKALEDAGIVASNSKMYDLKD
IVVAVESAVGARPKLRCDEEGLVQKLSLCFDKDFKPRDCVQVGSCPRYVS
LPEIPD

Ligand information

• Ligand ID: SO4
• InChI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
• InChIKey: QAOWNCQODCNURD-UHFFFAOYSA-L
• SMILES:
  OpenEye OEToolkits 1.5.0: [O-]S(=O)(=O)[O-]
  CACTVS 3.341: [O-][S]([O-])(=O)=O
  ACDLabs 10.04: [O-]S([O-])(=O)=O
• Formula: O4 S
• Name: SULFATE ION
• DrugBank: DB14546
• PDB chain: 1sgl Chain A Residue 253

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1sgl The three-dimensional structure and X-ray sequence reveal that trichomaglin is a novel S-like ribonuclease.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): R46 K167
• Binding residue (residue number reindexed from 1): R43 K164
• Annotation score: 3

Enzymatic activity

• Catalytic site (original residue number in PDB): H43 R46 E53 I96 L97 Q101
• Catalytic site (residue number reindexed from 1): H40 R43 E50 I93 L94 Q98
• Enzyme Commision number: 3.1.-.-

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004521 RNA endonuclease activity
• GO:0033897 ribonuclease T2 activity

Biological Process

• GO:0006401 RNA catabolic process

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:1sgl, PDBe:1sgl, PDBj:1sgl
• PDBsum: 1sgl
• PubMed: 15274921
• UniProt: E0CX00