Structure of PDB 1r6x Chain A Binding Site BS03

Receptor Information

>1r6x Chain A (length=386) Species: 4932 (Saccharomyces cerevisiae)

PAPHGGILQDLIARDALKKNELLSEAQSSDILVWNLTPRQLCDIELILNG
GFSPLTGFLNENDYSSVVTDSRLADGTLWTIPITLDVDEAFANQIKPDTR
IALFQDDEIPIAILTVQDVYKPNKTIEAEKVFRGDPEHPAISYLFNVAGD
YYVGGSLEAIQLPQHYDYPGLRKTPAQLRLEFQSRQWDRVVAFQTRNPMH
RAHRELTVRAAREANAKVLIHPVVGLTKPGDIDHHTRVRVYQEIIKRYPN
GIAFLSLLPLAMRMSGDREAVWHAIIRKNYGASHFIVGRDHAGPGKNSKG
VDFYGPYDAQELVESYKHELDIEVVPFRMVTYLPDEDRYAPIDQIDTTKT
RTLNISGTELRRRLRVGGEIPEWFSYPEVVKILRES

Ligand information

• Ligand ID: CO
• InChI: InChI=1S/Co/q+2
• InChIKey: XLJKHNWPARRRJB-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Co+2]
  CACTVS 3.341: [Co++]
• Formula: Co
• Name: COBALT (II) ION
• DrugBank: DB14205
• PDB chain: 1r6x Chain A Residue 3000

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1r6x Structural and functional analysis of a truncated form of Saccharomyces cerevisiae ATP sulfurylase: C-terminal domain essential for oligomer formation but not for activity
• Resolution: 1.4 Å
• Binding residue (original residue number in PDB): D168 H235 H236
• Binding residue (residue number reindexed from 1): D167 H234 H235
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): T196 R197 H201 H204 R290
• Catalytic site (residue number reindexed from 1): T195 R196 H200 H203 R289
• Enzyme Commision number: 2.7.7.4: sulfate adenylyltransferase.

Gene Ontology

Molecular Function

• GO:0004781 sulfate adenylyltransferase (ATP) activity

Biological Process

• GO:0000103 sulfate assimilation

External links

• PDB: RCSB:1r6x, PDBe:1r6x, PDBj:1r6x
• PDBsum: 1r6x
• PubMed: 14983089
• UniProt: P08536|MET3_YEAST Sulfate adenylyltransferase (Gene Name=MET3)