Structure of PDB 1p2s Chain A Binding Site BS03

Receptor Information
>1p2s Chain A (length=166) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQI
KRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQ
GVEDAFYTLVREIRQH
Ligand information
Ligand IDETF
InChIInChI=1S/C2H3F3O/c3-2(4,5)1-6/h6H,1H2
InChIKeyRHQDFWAXVIIEBN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341OCC(F)(F)F
ACDLabs 10.04FC(F)(F)CO
OpenEye OEToolkits 1.5.0C(C(F)(F)F)O
FormulaC2 H3 F3 O
NameTRIFLUOROETHANOL
ChEMBLCHEMBL116675
DrugBankDB03226
ZINCZINC000003860799
PDB chain1p2s Chain A Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1p2s Organic Solvents Order the Dynamic Switch II in Ras Crystals
Resolution2.45 Å
Binding residue
(original residue number in PDB)		R97 K101 D107
Binding residue
(residue number reindexed from 1)		R97 K101 D107
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1p2s, PDBe:1p2s, PDBj:1p2s
PDBsum1p2s
PubMed12842038
UniProtP01112|RASH_HUMAN GTPase HRas (Gene Name=HRAS)

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