Structure of PDB 1o6k Chain A Binding Site BS03

Receptor Information

>1o6k Chain A (length=318) Species: 9606 (Homo sapiens)

KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVA
HTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRER
VFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFG
LCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC
GRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGG
GPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTA
QSITQRTHFPQFDYSASI

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 1o6k Chain A Residue 1481

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1o6k Crystal Structure of an Activated Akt/Protein Kinase B Ternary Complex with Gsk-3 Peptide and AMP-Pnp
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): N280 D293
• Binding residue (residue number reindexed from 1): N135 D148
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D275 K277 N280 D293 T313
• Catalytic site (residue number reindexed from 1): D130 K132 N135 D148 T168
• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004674 protein serine/threonine kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:1o6k, PDBe:1o6k, PDBj:1o6k
• PDBsum: 1o6k
• PubMed: 12434148
• UniProt: P31751|AKT2_HUMAN RAC-beta serine/threonine-protein kinase (Gene Name=AKT2)