Structure of PDB 1nh3 Chain A Binding Site BS03

Receptor Information
>1nh3 Chain A (length=471) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPK
AEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCDF
TQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIAN
FKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWK
EVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKK
CVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTV
GCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQ
LFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQL
KELTAPDENIPAKILSYNRANRAVSKLNYLDPRITVAWCKKWGVPIEKIY
NKTQREKFAWAIDMADEDYEF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1nh3 Structural Impact of the Leukemia Drug 1-beta-D-Arabinofuranosylcytosine (Ara-C) on the Covalent Human Topoisomerase I-DNA Complex
Resolution3.1 Å
Binding residue
(original residue number in PDB)		K354 E356 F361 H367 K374 K425 R488 A489 G490 N491 K493 T501 K532 T585 A586 K587 N745
Binding residue
(residue number reindexed from 1)		K152 E154 F159 H165 K172 K223 R286 A287 G288 N289 K291 T299 K330 T383 A384 K385 N451
Enzymatic activity
Enzyme Commision number 5.6.2.1: DNA topoisomerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
Biological Process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1nh3, PDBe:1nh3, PDBj:1nh3
PDBsum1nh3
PubMed12533542
UniProtP11387|TOP1_HUMAN DNA topoisomerase 1 (Gene Name=TOP1)

[Back to BioLiP]