Structure of PDB 1kcw Chain A Binding Site BS03

Receptor Information
>1kcw Chain A (length=1017) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGPDRIGRLYKK
ALYLQYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTF
HSHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGE
GDGNCVTRIYHSHIDAPKDIASGLIGPLIICKKDSLDKEKEKHIDREFVV
MFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDFQESNRMYSVNGYTFGS
LPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINLFPA
TLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECIRGKHVRHYYIA
AEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYRE
YTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEP
IGVRFNKNNEGTYYSPVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCL
AKMYYSAVDPTKDIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVF
DENESLLLEDNIRMFTTAPDQVDKEDEDFQESNKMHSMNGFMYGNQPGLT
MCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRDTANLFPQTSLTL
HMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSEDSTFYLGERTYY
IAAVEVEWDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIGSKYKKVVYR
QYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIH
AHGVQTESSTVTPTLPGETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQ
VKDLYSGLIGPLIVCRRPRRKLEFALLFLVFDENESWYLDDNIKTYSDHP
EKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNEID
LHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTLEMFPRTPGIWLLHCHV
TDHIHAGMETTYTVLQN
Ligand information
Ligand IDCU
InChIInChI=1S/Cu/q+2
InChIKeyJPVYNHNXODAKFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Cu+2]
CACTVS 3.341[Cu++]
FormulaCu
NameCOPPER (II) ION
ChEMBL
DrugBankDB14552
ZINC
PDB chain1kcw Chain A Residue 1051 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1kcw The X-ray structure of human serum ceruloplasmin at 3.1 angstrom: Nature of the copper centres.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		H103 H161 H1022
Binding residue
(residue number reindexed from 1)		H103 H161 H999
Annotation score1
Enzymatic activity
Enzyme Commision number 1.11.1.27: glutathione-dependent peroxiredoxin.
1.11.1.9: glutathione peroxidase.
1.16.3.1: ferroxidase.
1.16.3.4: cuproxidase.
Gene Ontology
Molecular Function
GO:0004322 ferroxidase activity
GO:0004602 glutathione peroxidase activity
GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity
GO:0016724 oxidoreductase activity, acting on metal ions, oxygen as acceptor
GO:0046872 metal ion binding
GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity
GO:0051087 protein-folding chaperone binding
Biological Process
GO:0006826 iron ion transport
GO:0006878 intracellular copper ion homeostasis
GO:0006879 intracellular iron ion homeostasis
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005765 lysosomal membrane
GO:0005788 endoplasmic reticulum lumen
GO:0005886 plasma membrane
GO:0070062 extracellular exosome
GO:0072562 blood microparticle

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1kcw, PDBe:1kcw, PDBj:1kcw
PDBsum1kcw
PubMed
UniProtP00450|CERU_HUMAN Ceruloplasmin (Gene Name=CP)

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