Structure of PDB 1jba Chain A Binding Site BS03

Receptor Information

>1jba Chain A (length=189) Species: 9913 (Bos taurus)

GQQFSWEEAEENGAVGAADAAQLQEWYKKFLEECPSGTLFMHEFKRFFKV
PDNEEATQYVEAMFRAFDTNGDNTIDFLEYVAALNLVLRGTLEHKLKWTF
KIYDKDRNGCIDRQELLDIVESIYKLKKACSVEVEAEQQGKLLTPEEVVD
RIFLLVDENGDGQLSLNEFVEGARRDKWVMKMLQMDLNP

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 1jba Chain A Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1jba Three-dimensional structure of guanylyl cyclase activating protein-2, a calcium-sensitive modulator of photoreceptor guanylyl cyclases.
• Resolution: N/A
• Binding residue (original residue number in PDB): D158 N160 D162 Q164 E169
• Binding residue (residue number reindexed from 1): D157 N159 D161 Q163 E168
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 4.6.1.2: guanylate cyclase.

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding
• GO:0008048 calcium sensitive guanylate cyclase activator activity
• GO:0046872 metal ion binding

Biological Process

• GO:0007601 visual perception

Cellular Component

• GO:0001750 photoreceptor outer segment
• GO:0001917 photoreceptor inner segment
• GO:0005886 plasma membrane
• GO:0042995 cell projection
• GO:0120199 cone photoreceptor outer segment

External links

• PDB: RCSB:1jba, PDBe:1jba, PDBj:1jba
• PDBsum: 1jba
• PubMed: 10383444
• UniProt: P51177|GUC1B_BOVIN Guanylyl cyclase-activating protein 2 (Gene Name=GUCA1B)