Structure of PDB 1hvf Chain A Binding Site BS03

Receptor Information
>1hvf Chain A (length=313) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VLRGTVTDFPGFDGRADAETLRKAMKGLGTDEESILTLLTSRSNAQRQEI
SAAFKTLFGRDLLDDLKSELTGKFQKLIVALMKPSRLYDAYELKHALKGA
GTNEKVLTEIIASRTPEELRAIKQVYEEEYGSSLEDDVVGDTSGYYQRML
VVLLQANRDPDAGIDEAQVEQDAQALFQAGELKWGTDEEKFITIFGTRSV
SHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIRSIPAYLAE
TLYYAMKGAGTDDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYSMIKGD
TSGDYKKALLLLC
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1hvf Chain A Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1hvf Structural and electrophysiological analysis of annexin V mutants. Mutagenesis of human annexin V, an in vitro voltage-gated calcium channel, provides information about the structural features of the ion pathway, the voltage sensor and the ion selectivity filter
Resolution2.0 Å
Binding residue
(original residue number in PDB)		M28 G30 G32 E72
Binding residue
(residue number reindexed from 1)		M25 G27 G29 E69
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001786 phosphatidylserine binding
GO:0004859 phospholipase inhibitor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0005544 calcium-dependent phospholipid binding
Biological Process
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0043066 negative regulation of apoptotic process
GO:0050819 negative regulation of coagulation
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0009897 external side of plasma membrane
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0042383 sarcolemma
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0072563 endothelial microparticle

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1hvf, PDBe:1hvf, PDBj:1hvf
PDBsum1hvf
PubMed8151707
UniProtP08758|ANXA5_HUMAN Annexin A5 (Gene Name=ANXA5)

[Back to BioLiP]