Structure of PDB 1hv5 Chain A Binding Site BS03

Receptor Information

>1hv5 Chain A (length=162) Species: 10090 (Mus musculus)

MFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFT
EVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYD
ETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLS
PDDRRGIQHLYG

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 1hv5 Chain A Residue 5503

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1hv5 Crystal structure of the stromelysin-3 (MMP-11) catalytic domain complexed with a phosphinic inhibitor mimicking the transition-state.
• Resolution: 2.6 Å
• Binding residue (original residue number in PDB): D175 G176 G178 I180 D198 E201
• Binding residue (residue number reindexed from 1): D75 G76 G78 I80 D98 E101
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): H219 E220 H223 H229
• Catalytic site (residue number reindexed from 1): H119 E120 H123 H129
• Enzyme Commision number: 3.4.24.-

Gene Ontology

Molecular Function

• GO:0004222 metalloendopeptidase activity
• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0031012 extracellular matrix

External links

• PDB: RCSB:1hv5, PDBe:1hv5, PDBj:1hv5
• PDBsum: 1hv5
• PubMed: 11254383
• UniProt: Q02853|MMP11_MOUSE Stromelysin-3 (Gene Name=Mmp11)