Structure of PDB 1h76 Chain A Binding Site BS03

Receptor Information
>1h76 Chain A (length=677) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QKTVRWCTISNQEANKCSSFRENMSKAVKNGPLVSCVKKSSYLDCIKAIR
DKEADAVTLDAGLVFEAGLAPYNLKPVVAEFYGQKDNPQTHYYAVAVVKK
GSNFQWNQLQGKRSCHTGLGRSAGWIIPMGLLYDQLPEPRKPIEKAVASF
FSSSCVPCADPVNFPKLCQQCAGKGAEKCACSNHEPYFGYAGAFNCLKED
AGDVAFVKHSTVLENLPDKADRDQYELLCRDNTRRPVDDYENCYLAQVPS
HAVVARSVDGQEDSIWELLNQAQEHFGRDKSPDFQLFSSSHGKDLLFKDS
ANGFLKIPSKMDSSLYLGYQYVTALRNLREEECKKVRWCAIGHEETQKCD
AWSINSGGKIECVSAENTEDCIAKIVKGEADAMSLDGGYIYIAGKCGLVP
VLAENYKTEGENCVNTPEKGYLAVAVVKKSSGPDLNWNNLKGKKSCHTAV
DRTAGWNIPMGLLYNKINSCKFDQFFGEGCAPGSQRNSSLCALCIGSERA
PGRECLANNHERYYGYTGAFRCLVEKGDVAFVKDQVVQQNTDGKNKDDWA
KDLKQMDFELLCQNGAREPVDNAENCHLARAPNHAVVARDDKVTCVAEEL
LKQQAQFGRHVTDCSSSFCMFKSNTKDLLFRDDTQCLARVGKTTYESYLG
ADYITAVANLRKCSTSKLLEACTFHSA
Ligand information
Ligand IDFE
InChIInChI=1S/Fe/q+3
InChIKeyVTLYFUHAOXGGBS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Fe+3]
FormulaFe
NameFE (III) ION
ChEMBL
DrugBankDB13949
ZINC
PDB chain1h76 Chain A Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1h76 The Crystal and Molecular Structures of Diferric Porcine and Rabbit Serum Transferrins at Resolutions of 2.15 And 2.60A, Respectively
Resolution2.15 Å
Binding residue
(original residue number in PDB)		D62 Y94 Y192 H253
Binding residue
(residue number reindexed from 1)		D60 Y92 Y190 H251
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008199 ferric iron binding
GO:0046872 metal ion binding
Biological Process
GO:0006826 iron ion transport
GO:0006879 intracellular iron ion homeostasis
GO:0019731 antibacterial humoral response
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0055037 recycling endosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1h76, PDBe:1h76, PDBj:1h76
PDBsum1h76
PubMed11752780
UniProtP09571|TRFE_PIG Serotransferrin (Gene Name=TF)

[Back to BioLiP]