Structure of PDB 1h5y Chain A Binding Site BS03

Receptor Information
>1h5y Chain A (length=252) Species: 13773 (Pyrobaculum aerophilum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMALRIIPCLDIDGGAKVVVKGVNFQGIREVGDPVEMAVRYEEEGADEIA
ILDITAAPEGRATFIDSVKRVAEAVSIPVLVGGGVRSLEDATTLFRAGAD
KVSVNTAAVRNPQLVALLAREFGSQSTVVAIDAKWNGEYYEVYVKGGREA
TGLDAVKWAKEVEELGAGEILLTSIDRDGTGLGYDVELIRRVADSVRIPV
IASGGAGRVEHFYEAAAAGADAVLAASLFHFRVLSIAQVKRYLKERGVEV
RI
Ligand information
Ligand IDGOL
InChIInChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
InChIKeyPEDCQBHIVMGVHV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C(C(CO)O)O
ACDLabs 12.01
CACTVS 3.370		OCC(O)CO
FormulaC3 H8 O3
NameGLYCEROL;
GLYCERIN;
PROPANE-1,2,3-TRIOL
ChEMBLCHEMBL692
DrugBankDB09462
ZINCZINC000000895048
PDB chain1h5y Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1h5y Structure of Hisf, a Histidine Biosynthetic Protein from Pyrobaculum Aerophilum
Resolution2.0 Å
Binding residue
(original residue number in PDB)		N106 A131 D133
Binding residue
(residue number reindexed from 1)		N105 A130 D132
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D12 D133
Catalytic site (residue number reindexed from 1) D11 D132
Enzyme Commision number 4.3.2.10: imidazole glycerol-phosphate synthase.
Gene Ontology
Molecular Function
GO:0000107 imidazoleglycerol-phosphate synthase activity
GO:0016829 lyase activity
Biological Process
GO:0000105 L-histidine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1h5y, PDBe:1h5y, PDBj:1h5y
PDBsum1h5y
PubMed11679715
UniProtQ8ZY16|HIS6_PYRAE Imidazole glycerol phosphate synthase subunit HisF (Gene Name=hisF)

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