Structure of PDB 1dtl Chain A Binding Site BS03

Receptor Information

>1dtl Chain A (length=149) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

YKAAVEQLTEEQKNEFKAAFDIFVLGAEDGSISTKELGKVMRMLGQNPTP
EELQEMIDEVDEDGSGTVDFDEFLVMMVRSMKKSEEELSDLFRMFDKNAD
GYIDLEELKIMLQATTITEDDIEELMKDGDKNNDGRIDYDEFLEFMKGV

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

1dtl Chain A Residue 203 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1dtl Bepridil opens the regulatory N-terminal lobe of cardiac troponin C.
Resolution	2.15 Å
Binding residue (original residue number in PDB)	D141 N143 D145 R147 E152
Binding residue (residue number reindexed from 1)	D130 N132 D134 R136 E141
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding
GO:0031013	troponin I binding
GO:0046872	metal ion binding
GO:0048306	calcium-dependent protein binding

	Biological Process
GO:0003009	skeletal muscle contraction
GO:0060048	cardiac muscle contraction

	Cellular Component
GO:1990584	cardiac Troponin complex

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Cellular Component

External links

PDB	RCSB:1dtl, PDBe:1dtl, PDBj:1dtl
PDBsum	1dtl
PubMed	10792039
UniProt	P09860\|TNNC1_CHICK Troponin C, slow skeletal and cardiac muscles (Gene Name=TNNC1)

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