Structure of PDB 1blz Chain A Binding Site BS03

Receptor Information

>1blz Chain A (length=327) Species: 162425 (Aspergillus nidulans)

SKANVPKIDVSPLFGDDQAAKMRVAQQIDAASRDTGFFYAVNHGINVQRL
SQKTKEFHMSITPEEKWDLAIRAYNKEHQDQVRAGYYLSIPGKKAVESFC
YLNPNFTPDHPRIQAKTPTHEVNVWPDETKHPGFQDFAEQYYWDVFGLSS
ALLKGYALALGKEENFFARHFKPDDTLASVVLIRYPYLDPYPEAAIKTAA
DGTKLSFEWHEDVSLITVLYQSNVQNLQVETAAGYQDIEADDTGYLINCG
SYMAHLTNNYYKAPIHRVKWVNAERQSLPFFVNLGYDSVIDPFDPREPNG
KSDREPLSYGDYLQNGLVSLINKNGQT

Ligand information

• Ligand ID: NO
• InChI: InChI=1S/HNO/c1-2/h1H
• InChIKey: ODUCDPQEXGNKDN-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.385
  OpenEye OEToolkits 2.0.7: [N]=O
• Formula: N O
• Name: NITRIC OXIDE;
  Nitrogen monoxide
• ChEMBL: CHEMBL1234765
• PDB chain: 1blz Chain A Residue 334

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1blz Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.
• Resolution: 1.45 Å
• Binding residue (original residue number in PDB): H214 H270
• Binding residue (residue number reindexed from 1): H210 H266
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): L186 F211 H214 D216 H270
• Catalytic site (residue number reindexed from 1): L182 F207 H210 D212 H266
• Enzyme Commision number: 1.21.3.1: isopenicillin-N synthase.

Gene Ontology

Molecular Function

• GO:0005506 iron ion binding
• GO:0016216 isopenicillin-N synthase activity
• GO:0016491 oxidoreductase activity
• GO:0031418 L-ascorbic acid binding
• GO:0046872 metal ion binding

Biological Process

• GO:0009058 biosynthetic process
• GO:0017000 antibiotic biosynthetic process
• GO:0042318 penicillin biosynthetic process
• GO:0044283 small molecule biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:1blz, PDBe:1blz, PDBj:1blz
• PDBsum: 1blz
• PubMed: 9194566
• UniProt: P05326|IPNA_EMENI Isopenicillin N synthase (Gene Name=ipnA)