Structure of PDB 1bht Chain A Binding Site BS03

Receptor Information

>1bht Chain A (length=176) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

RRNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTC
KAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGR
SYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEE
GGPWCFTSNPEVRYEVCDIPQCSEVE

Ligand information

Ligand ID

EPE

InChI

InChI=1S/C8H18N2O4S/c11-7-5-9-1-3-10(4-2-9)6-8-15(12,13)14/h11H,1-8H2,(H,12,13,14)

InChIKey

JKMHFZQWWAIEOD-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04	O=S(=O)(O)CCN1CCN(CCO)CC1
OpenEye OEToolkits 1.5.0	C1CN(CCN1CCO)CCS(=O)(=O)O
CACTVS 3.341	OCCN1CCN(CC1)CC[S](O)(=O)=O

Formula

C8 H18 N2 O4 S

Name

4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID;
HEPES

PDB chain

1bht Chain A Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1bht Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0 A resolution.
Resolution	2.0 Å
Binding residue (original residue number in PDB)	E183 W188 F190 R197 Y198 V200
Binding residue (residue number reindexed from 1)	E149 W154 F156 R163 Y164 V166
Annotation score	1

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:1bht, PDBe:1bht, PDBj:1bht
PDBsum	1bht
PubMed	9817840
UniProt	P14210\|HGF_HUMAN Hepatocyte growth factor (Gene Name=HGF)

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