Structure of PDB 1aii Chain A Binding Site BS03

Receptor Information
>1aii Chain A (length=322) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASIWVGHRGTVRDYPDFSPSVDAEAIQKAIRGIGTDEKMLISILTERSNA
QRQLIVKEYQAAYGKELKDDLKGDLSGHFEHLMVALVTPPAVFDAKQLKK
SMKGAGTNEDALIEILTTRTSRQMKDISQAYYTVYKKSLGDDISSETSGD
FRKALLTLADGRRDESLKVDEHLAKQDAQILYKAGENRWGTDEDKFTEIL
CLRSFPQLKLTFDEYRNISQKDIVDSIKGELSGHFEDLLLAIVNCVRNTP
AFLAERLHRALKGIGTDEFTLNRIMVSRSEIDLLDIRTEFKKHYGYSLYS
AIKSDTSGDYEITLLKICGGDD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1aii Chain A Residue 354 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1aii Can enzymatic activity, or otherwise, be inferred from structural studies of annexin III?
Resolution1.95 Å
Binding residue
(original residue number in PDB)		K230 L233 E238
Binding residue
(residue number reindexed from 1)		K228 L231 E236
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001786 phosphatidylserine binding
GO:0004859 phospholipase inhibitor activity
GO:0005509 calcium ion binding
GO:0005544 calcium-dependent phospholipid binding
GO:0019834 phospholipase A2 inhibitor activity
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0006909 phagocytosis
GO:0010595 positive regulation of endothelial cell migration
GO:0021766 hippocampus development
GO:0031100 animal organ regeneration
GO:0042742 defense response to bacterium
GO:0043312 neutrophil degranulation
GO:0045766 positive regulation of angiogenesis
GO:0051054 positive regulation of DNA metabolic process
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051384 response to glucocorticoid
GO:0070848 response to growth factor
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0030670 phagocytic vesicle membrane
GO:0042581 specific granule
GO:0043025 neuronal cell body
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1aii, PDBe:1aii, PDBj:1aii
PDBsum1aii
PubMed9111038
UniProtP12429|ANXA3_HUMAN Annexin A3 (Gene Name=ANXA3)

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