Structure of PDB 1a25 Chain A Binding Site BS03

Receptor Information
>1a25 Chain A (length=132) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ERRGRIYIQAHIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKS
ESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFM
GSLSFGISELQKAGVDGWFKLLSQEEGEYFNV
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1a25 Chain A Residue 292 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1a25 Structure of the protein kinase Cbeta phospholipid-binding C2 domain complexed with Ca2+.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		D248 S251 R252 D254
Binding residue
(residue number reindexed from 1)		D92 S95 R96 D98
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.13: protein kinase C.
External links
PDB RCSB:1a25, PDBe:1a25, PDBj:1a25
PDBsum1a25
PubMed9817842
UniProtP68403|KPCB_RAT Protein kinase C beta type (Gene Name=Prkcb)

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