Structure of PDB 7zki Chain 7 Binding Site BS03

Receptor Information
>7zki Chain 7 (length=595) Species: 272844 (Pyrococcus abyssi GE5) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RIRQPIIAVLGHVDHGKTTLLDRIRKTNVAAKEAGGITQHIGATEVPIEV
VKKIAGPLIKLWKAEIKLPGLLFIDTPGHEAFTSLRARGGSLADLAVLVV
DINEGFQPQTIESIEILRKYRTPFVVAANKIDRIKGWVIEEDEPFLMNIK
KQDQRAVQELETKLWELIGKFYEFGFQANRFDRVQNFTRELAIVPISAKY
GIGIAELLVLIAGLSQRYLEEKLKIEVEGPARGTILEVREEPGLGHTIDV
IIYDGTLHKDDTIVVGGKDKAIVTKIRALLKPKPLDEIRDPRFRFDYVDE
VTAAAGVKIAAPGLEEALAGSPVIAAPTPEDVEKAKQEILEQIERVVIST
DKVGVIVKADTLGSLEALSKELQEKEIPIRKADVGNVSKTDVMEALSVKE
EEPKYGVILGFNVKVNEDAEEVAKAKDVKIFVGNVIYKLIEDYEEWVKEE
EEKKKRELLSKVTFPGVIRLYPDERYVFRRSNPAIVGIEVIEGRIKPGVT
LIKQNGQKVGVIRSIKSRDEFLQEAKKGQAVAIAIEGAIVGRHIHPGETL
YVDLSRDDAITLLKHLRDTLEDTDIKALKMIAKVKAKEDPFWRAI
Ligand information
Ligand IDGNP
InChIInChI=1S/C10H17N6O13P3/c11-10-13-7-4(8(19)14-10)12-2-16(7)9-6(18)5(17)3(28-9)1-27-32(25,26)29-31(23,24)15-30(20,21)22/h2-3,5-6,9,17-18H,1H2,(H,25,26)(H3,11,13,14,19)(H4,15,20,21,22,23,24)/t3-,5-,6-,9-/m1/s1
InChIKeyUQABYHGXWYXDTK-UUOKFMHZSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=P(O)(O)NP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
OpenEye OEToolkits 1.5.0c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@@](=O)(NP(=O)(O)O)O)O)O)N=C(NC2=O)N
OpenEye OEToolkits 1.5.0c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(NP(=O)(O)O)O)O)O)N=C(NC2=O)N
CACTVS 3.341NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P@@](O)(=O)N[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.341NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)N[P](O)(O)=O)[CH](O)[CH]3O
FormulaC10 H17 N6 O13 P3
NamePHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
ChEMBLCHEMBL1233085
DrugBankDB02082
ZINCZINC000037868676
PDB chain7zki Chain 7 Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7zki Role of aIF5B in archaeal translation initiation.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		D17 G19 K20 T21 T22 K133 D135 K202
Binding residue
(residue number reindexed from 1)		D14 G16 K17 T18 T19 K130 D132 K199
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003743 translation initiation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006413 translational initiation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7zki, PDBe:7zki, PDBj:7zki
PDBsum7zki
PubMed35694843
UniProtQ9UZK7|IF2P_PYRAB Probable translation initiation factor IF-2 (Gene Name=infB)

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