Structure of PDB 7pfo Chain 7 Binding Site BS03

Receptor Information
>7pfo Chain 7 (length=595) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYVDL
DDVAEDDPELVDSICENARRYAKLFADAVQELLPQYKEDVYIEHRLMMEQ
RSRPAELMRRFELYFQGPSSNKPRVIREVRADSVGKLVTVRGIVTRVSEV
KPKMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQ
TRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSV
TGIFLPILRTGFRQVVQGLLSETYLEAHRIVKMDFYEKLAASIAPEIYGH
EDVKKALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRL
APRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEF
DKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNP
RRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQP
PSQFEPLDMKLMRRYIAMCREKQPMVPESLADYITAAYVEMRREAWASTY
TSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7pfo Chain 7 Residue 1000 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7pfo Structure of a human replisome shows the organisation and interactions of a DNA replication machine.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		C184 C187 C206 C211
Binding residue
(residue number reindexed from 1)		C161 C164 C183 C188
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006974 DNA damage response
GO:0008283 cell population proliferation
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032508 DNA duplex unwinding
GO:0042325 regulation of phosphorylation
GO:0071466 cellular response to xenobiotic stimulus
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0016020 membrane
GO:0042555 MCM complex
GO:0071162 CMG complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7pfo, PDBe:7pfo, PDBj:7pfo
PDBsum7pfo
PubMed34694004
UniProtP33993|MCM7_HUMAN DNA replication licensing factor MCM7 (Gene Name=MCM7)

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