Structure of PDB 7o4k Chain 7 Binding Site BS03

Receptor Information
>7o4k Chain 7 (length=608) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IPADFVPDSVSGMFRSHDFSYLRLRPDHASRPLWISPSDGRIILESFSPL
AEQAQDFLVTIAEPISRPSHIHEYKITAYSLYAAVSVGLETDDIISVLDR
LSKVPVAESIINFIKGATISYGKVKLVIKHNRYFVETTQADILQMLLNDS
VIGVHSFEIANESVEVVKKRCQEIDYPVLEEYDFRNDHRNPDLDIDLKPS
TQIRPYQEKSLSKMFGNGRARSGIIVLPCGAGKTLVGITAACTIKKSVIV
LCTSSVSVMQWRQQFLQWCTLQPENCAVFTSDNKEMFQTESGLVVSTYSM
VANTRNRSHDSQKVMDFLTGREWGFIILDEVHVVPAAMFRRVVSTIAAHA
KLGLTATLVREDDKIGDLNFLIGPKLYEANWMELSQKGHIANVQCAEVWC
PMTAEFYQEYLRETARKRMLLYIMNPTKFQACQFLIQYHERRGDKIIVFS
DNVYALQEYALKMGKPFIYGSTPQQERMNILQNFQYNDQINTIFLSKVGD
TSIDLPEATCLIQISSHYGSRRQEAQRLGRILRAKRRNDEGFNAFFYSLV
SKDTQEMYYSTKRQAFLVDQGYAFKVITHLHGMENIPNLAYASPRERREL
LQEVLLKN
Ligand information
Ligand IDBEF
InChIInChI=1S/Be.3FH/h;3*1H/q+2;;;/p-3
InChIKeyOGIAHMCCNXDTIE-UHFFFAOYSA-K
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[Be-](F)(F)F
ACDLabs 10.04
CACTVS 3.341		F[Be-](F)F
FormulaBe F3
NameBERYLLIUM TRIFLUORIDE ION
ChEMBL
DrugBank
ZINC
PDB chain7o4k Chain 7 Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7o4k Structure of RNA polymerase II pre-initiation complex at 2.9 angstrom defines initial DNA opening.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		C388 K392 R689 R692
Binding residue
(residue number reindexed from 1)		C229 K233 R530 R533
Annotation score1
Enzymatic activity
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0015616 DNA translocase activity
GO:0016787 hydrolase activity
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000019 regulation of mitotic recombination
GO:0001111 RNA polymerase II promoter clearance
GO:0001113 transcription open complex formation at RNA polymerase II promoter
GO:0001174 transcriptional start site selection at RNA polymerase II promoter
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0016973 poly(A)+ mRNA export from nucleus
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0000112 nucleotide-excision repair factor 3 complex
GO:0000439 transcription factor TFIIH core complex
GO:0005634 nucleus
GO:0005675 transcription factor TFIIH holo complex
GO:0005829 cytosol
GO:0097550 transcription preinitiation complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7o4k, PDBe:7o4k, PDBj:7o4k
PDBsum7o4k
PubMed34133942
UniProtQ00578|RAD25_YEAST General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2 (Gene Name=SSL2)

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