Structure of PDB 8p18 Chain 6 Binding Site BS03

Receptor Information

>8p18 Chain 6 (length=361) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

INPVNNRIQDLTERSDVLRGYLDYDAKKERLEEVNAELEQPDVWNEPERA
QALGKERSSLEAVVDTLDQMKQGLEDVSGLLELAVEADDEETFNEAVAEL
DALEEKLAQLEFRRMFSGEYDSADCYLDIQAGSGGTEAQDWASMLERMYL
RWAESRGFKTEIIKESEGEVAGIKSVTIKISGDYAYGWLRTETGVHRLVR
KSPFDSGGRRHTSFSSAFVYPEVDDDIDIEINPADLRIDVYRTSGAGGQH
VNRTESAVRITHIPTGIVTQCQNDRSQHKNKDQAMKQMKAKLYELEMQKK
NAEKQAMEDNKSDIGWGSQIRSYVLDDSRIKDLRTGVETRNTQAVLDGSL
DQFIEASLKAG

Ligand information

>8p18 Chain 5 (length=76) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgu
cgguucaaauccggcccccgcaacca

<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<
<<<.......>>>>>>>>>>>.....

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8p18 The compensatory mechanism of a naturally evolved E167K RF2 counteracting the loss of RF1 in bacteria
Resolution	2.77 Å
Binding residue (original residue number in PDB)	G250 V254 R278
Binding residue (residue number reindexed from 1)	G247 V251 R275

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0016149	translation release factor activity, codon specific

	Biological Process
GO:0006412	translation
GO:0006415	translational termination
GO:0075523	viral translational frameshifting

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol

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Cellular Component

External links

PDB	RCSB:8p18, PDBe:8p18, PDBj:8p18
PDBsum	8p18
PubMed
UniProt	P07012\|RF2_ECOLI Peptide chain release factor RF2 (Gene Name=prfB)

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