Structure of PDB 6lqp Chain 5C Binding Site BS03

Receptor Information
>6lqp Chain 5C (length=535) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KERENQNKFERSTYTNNQTKDKKLRAGLKKIDEQYKKAVSSAAATDYLLP
ESNGYLEPENELEKTFKVQQSEIKSSVDVSTANKALDLSLKEFGPYHIKY
AKNGTHLLITGRKGHVASMDWRKGQLRAELFLNETCHSATYLQNEQYFAV
AQKKYTFIYDHEGTELHRLKQHIEARHLDFLPYHYLLVTAGETGWLKYHD
VSTGQLVSELRTKAGPTMAMAQNPWNAVMHLGHSNGTVSLWSPSMPEPLV
KLLSARGPVNSIAIDRSGYYMATTGADRSMKIWDIRNFKQLHSVESLPTP
GTNVSISDTGLLALSRGPHVTLWKDALKLSGDSKPCFGSMGGNPHRNTPY
MSHLFAGNKVENLGFVPFEDLLGVGHQTGITNLIVPGAGEANYDALELNP
FETKKQRQEQEVRTLLNKLPADTITLDPNSIGSVDKRSSTIRLNAKDLAQ
TTMDANNKAKTNSDIPDVKPDVKGKNSGLRSFLRKKTQNVIDERKLRVQK
QLDKEKNIRKRNHQIKQGLISEDHKDVIEEALSRF
Ligand information
>6lqp Chain SA (length=1325) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aagauaguuaucugguugauccugccaguagucauaugcuugucucagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaaggcucau
uaaaucaguuaucguuuauuugauaguuccaugguauaacugugguaauu
cuagagcuaauacaugcuaaucucgacccuuuggaagagauguauuuauu
agaucaaugucuucggacucuuugaugaaauaacuuuucgaaucgcaugg
ccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgau
gguaggauaguggccuaccaugguuucaacggguaacggggaauaagggu
ucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggc
agcaggccaaauuacccaauccuaauucagggagguagugacaauaaaua
acgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaa
uaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgg
uaauuccagcuccaauagcguauauuaaaguuguugcagaagcucguagu
ugaacuggcccgguuggccgguccggauuuccaacggggccuugguucuc
uaggacugauuaauagggacggucgggggcaucaguauucaauugucaga
ggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugcc
aaggacguuuucauuaaucaagaacgaccauaaacuaugccgacuaggga
ucgggugguguuuuuuuaaugacccacucggcaccuuacgagaacugggg
ggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcacca
ccaggaguggagccugcggcucaacacggggaaacucaccagguccagac
acaauaaggauugacauucuugauuuugugggugguggugcauugaugcc
cuuguucugggccacgcgcgcuacacugacggagccagcgagucuaaccu
uggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauau
ucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacg
ucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuu
agugaggccucaggaucugcuuagagaagggggcaacuccaucucagagc
ggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaa
gguuuccguaggugaaccugcggaa
............................<<<<.<<<<<<........<<<
.<<...<<....<<....<<..........>>...>>.>>.....<<<..
.....<<<..<<..<<....<<<..........<.....<<.<<......
.>>.>>......>.......<<<<............>>>>.....<<<<<
...<<<<..............>>>>...>>>>>.........<<<<...<
<.....>>..>>>>....>>>...>>>>..>>>.<<<....<<<....<<
<<<<<<.......>>>>>>>>>>>......>>>.....<<..........
.....>>..>>>.<<.<<<..........>>>.>>.<.<<....>>.>..
..>>>>>......<<<....<<<.....>>>..>>>..............
.<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<<..<.......
....>..>>.........<<<<<<.......<<<....>>>.........
.........>>>>>>..>>>>>>>>>>.........<....<.<<...<<
<.<<..<<<<<.<<<<<..<.......>..>>>>>.>>>>>....<....
.>.......>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<
<......>>>......>.>>>>>>..>>.......<<....>>...>>>>
...>>>>>.>>>...>>>...>>.>...............<<...<<<..
<<<<<<<<.<<<........>>>>>>>>>>>..>>>..>>......>...
.................<<.........>>.....<<<<<<<<<<<<..<
<.<<<<<<..<<<.<<<<.......................<<.<....<
<<<<........<.....>......>>>>>......<<<........>>>
...>.>>.......>>>>.>>>.....<<<<<<<............<<<.
.<<<<....>>>>..>>>............>>>>>>>.............
..........>>>>>>....<<<<<<<<.......>>>>>>>>......>
>...>>>>>>>............>>>>>..<<<<.<<.....<<<<<<<.
<<<..<.<<......<<<<<<<...<<.<<<......>>>.>>...>>>>
>>>......>>.>..>>>.>>>>>>>....>>.>>>>.............
...<<<<<<<<<....>>>>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6lqp Cryo-EM structure of 90 S small ribosomal subunit precursors in transition states.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		D39 K40 K41 A44 K464 A467
Binding residue
(residue number reindexed from 1)		D21 K22 K23 A26 K446 A449
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0030490 maturation of SSU-rRNA
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0030686 90S preribosome
GO:0030688 preribosome, small subunit precursor
GO:0032040 small-subunit processome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6lqp, PDBe:6lqp, PDBj:6lqp
PDBsum6lqp
PubMed32943522
UniProtP40055|UTP7_YEAST U3 small nucleolar RNA-associated protein 7 (Gene Name=UTP7)

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