Structure of PDB 8twb Chain 5 Binding Site BS03

Receptor Information
>8twb Chain 5 (length=338) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WVDKYRPKSLNALSHNEELTNFLKSLSDQPRDLPHLLLYGPNGTGKKTRC
MALLESIFGPGVYRLKIDVRQFVTASNRKLELNVVSSPYHLEITPSDMGN
NDRIVIQELLKEVAQMEHRYKCVIINEANSLTKDAQAALRRTMEKYSKNI
RLIMVCDSMSPIIAPIKSRCLLIRCPAPSDSEISTILSDVVTNERIQLET
KDILKRIAQASNGNLRVSLLMLESMALNNELALKSSSPIIKPDWIIVIHK
LTRKIVKERSVNSLIECRAVLYDLLAHCIPANIILKELTFSLLDVETLNT
TNKSSIIEYSSVFDERLSLGNKAIFHLEGFIAKVMCCL
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain8twb Chain 5 Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8twb Cryo-EM reveals that Ctf18-RFC collaborates with PolE to load the PCNA clamp onto a leading strand DNA
Resolution3.2 Å
Binding residue
(original residue number in PDB)		V5 P10 L16 S17 G46 G48 K49 K50 T51 L230 R231
Binding residue
(residue number reindexed from 1)		V2 P7 L13 S14 G43 G45 K46 K47 T48 L215 R216
Annotation score4
External links
PDB RCSB:8twb, PDBe:8twb, PDBj:8twb
PDBsum8twb
PubMed
UniProtP38251|RFC5_YEAST Replication factor C subunit 5 (Gene Name=RFC5)

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