Structure of PDB 8ouw Chain 5 Binding Site BS03

Receptor Information
>8ouw Chain 5 (length=541) Species: 6239 (Caenorhabditis elegans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TGRELIAEYRQLITQFRNFIRDFSTGGFGMIYRDQLKRNYFSHEYRLEIN
LNHLKNFDEDIEMKLRKFPGKVLPALEEAAKIVADEITTPRPKGEEKLHD
IQVTLTLDEYPTSLRQVKSAQVSQVVKISGIIVAAAQVRSKATKVTLQCR
QCKHTIPDVSIKPGLEGFALPRTCAACPIDPYIMLPDKCECVDYQTLKLQ
ENPEDVPHGEMPRHLQLFTERYLTDKVVPGNRVTIVGVYSIKKGIRTPYL
RVLGIHMETFTTFTPEEERMFKTLAQRKDAYELIAKSIAPSIYGSADIKK
SIACLLFGGARKKLPDGITRRGDINVLLLGDPGTAKSQLLKFVEQVSPIG
VYTSGAMVLADGGVVCIDEFDKIHEAMEQQTISIAKAGITTTLNSRCSVL
AAANSMPTILSRFDMIYIVKHDVLKDATLAKHVIEVHVNASAAKETMFDT
DGFLTIEFLKKFVTYARLNCGPRLTPQASEKLVNHYVKMRNPPITVRQLE
AIVRIAESIAKMELQQFATDKHVEEALRLFRVSTIEAAATG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8ouw Chain 5 Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8ouw DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans.
Resolution3.75 Å
Binding residue
(original residue number in PDB)		C172 C197
Binding residue
(residue number reindexed from 1)		C149 C174
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0006279 premeiotic DNA replication
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex
GO:0042555 MCM complex
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ouw, PDBe:8ouw, PDBj:8ouw
PDBsum8ouw
PubMed37590372
UniProtQ21902|MCM5_CAEEL DNA replication licensing factor mcm-5 (Gene Name=mcm-5)

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