Structure of PDB 8kme Chain 2 Binding Site BS03

Receptor Information
>8kme Chain 2 (length=250) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
Ligand information
Receptor-Ligand Complex Structure
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PDB8kme Structures of thrombin retro-inhibited with SEL2711 and SEL2770 as they relate to factor Xa binding.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		Y60A W60D I174 D189 A190 E192 S214 W215 G216 E217 G219
Binding residue
(residue number reindexed from 1)		Y47 W50 I172 D192 A193 E195 S219 W220 G221 E222 G223
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:8kme, PDBe:8kme, PDBj:8kme
PDBsum8kme
PubMed10089309
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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