Structure of PDB 5hau Chain 1z Binding Site BS03

Receptor Information
>5hau Chain 1z (length=730) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKVILLEPLENLGDVGQVVDVKPGYARNYLLPRGLAVLATESNLKALEAR
IRAQAKRLAERKAEAERLKEILENDLKRLRNIGIAAHIDAGKTTTTERIL
YYTGRIHAAVTTCFWKDHRINIIDTPGHVDFTIEVERSMRVLDGAIVVFD
SSQGVEPQSETVWRQAEKYKVPRIAFANKMDKTGADLWLVIRTMQERLGA
RPVVMQLPIGREDTFSGIIDVLRMKAYTYGNDLGTDIREIPIPEEYLDQA
REYHEKLVEVAADFDENIMLKYLEGEEPTEEELVAAIRKGTIDLKITPVF
LGSALKNKGVQLLLDAVVDYLPSPLDIPPIKGTTPEGEVVEIHPDPNGPL
AALAFKIMADPYVGRLTFIRVYSGTLTSGSYVYNTTKGRKERVARLLRMH
ANHREEVEELKAGDLGAVVGLKETITGDTLVGEDAPRVILESIEVPEPVI
DVAIEPKTKADQEKLSQALARLAEEDPTFRVSTHPETGQTIISGMGELHL
EIIVDRLKREFKVDANVGKPQVAYRETITKPVDVEGKFIRQTGGRGQYGH
VKIKVEPLPRGSGFEFVNAIVGGVIPKEYIPAVQKGIEEAMQSGPLIGFP
VVDIKVTLYDGSYHEVDSSEMAFKIAGSMAIKEAVQKGDPVILEPIMRVE
VTTPEEYMGDVIGDLNARRGQILGMEPRGNAQVIRAFVPLAEMFGYATDL
RSKTQGRGSFVMFFDHYQEVPKQVQEKLIK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5hau Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		G502 R504 S578
Binding residue
(residue number reindexed from 1)		G543 R545 S619
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
GO:0032790 ribosome disassembly
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5hau, PDBe:5hau, PDBj:5hau
PDBsum5hau
PubMed26809677
UniProtQ5SHN5|EFG_THET8 Elongation factor G (Gene Name=fusA);
Q5SLQ1|RL9_THET8 Large ribosomal subunit protein bL9 (Gene Name=rplI)

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