Structure of PDB 6zvj Chain 1 Binding Site BS03

Receptor Information
>6zvj Chain 1 (length=576) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLTRIAIVNHDKCKPKKCRQECKKSCPVVRMGKLCIEVTPQSKIAWISET
LCIGCGICIKKCPFGALSIVNLPSNLEKETTHRYCANAFKLHRLPIPRPG
EVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQ
NYFTKILEDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIVCQQ
LDLTHLKERNVEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRL
KAAITIRSLINPDRYIIVVEHDLSVLDYLSDFICCLYGVPSAYGVVTMPF
SVREGINIFLDGYVPTENLRFRDASYKYPGMKKKMGEFELAIVAGEFTDS
EIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVSYKPQKISPKSTG
SVRQLLHEKIRDAYTHPQFVTDVMKPLQIENIIDQEVQTLSGGELQRVAL
ALCLGKPADVYLIDEPSAYLDSEQRLMAARVVKRFILHAKKTAFVVEHDF
IMATYLADRVIVFDGVPSKNTVANSPQTLLAGMNKFLSQLEITFRRDPNN
YRPRINKLNSIKDVEQKKSGNYFFLD
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain6zvj Chain 1 Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6zvj A structural inventory of native ribosomal ABCE1-43S pre-initiation complexes.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		C16 P18 C21 Q23 C25 C65 L70
Binding residue
(residue number reindexed from 1)		C13 P15 C18 Q20 C22 C62 L67
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.-
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017111 ribonucleoside triphosphate phosphatase activity
GO:0043024 ribosomal small subunit binding
GO:0043273 CTPase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0060698 endoribonuclease inhibitor activity
Biological Process
GO:0000054 ribosomal subunit export from nucleus
GO:0006413 translational initiation
GO:0006415 translational termination
GO:0006417 regulation of translation
GO:0032790 ribosome disassembly
GO:0060702 negative regulation of endoribonuclease activity
GO:0072344 rescue of stalled ribosome
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0016020 membrane
GO:0022626 cytosolic ribosome

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6zvj, PDBe:6zvj, PDBj:6zvj
PDBsum6zvj
PubMed33289941
UniProtP61221|ABCE1_HUMAN ATP-binding cassette sub-family E member 1 (Gene Name=ABCE1)

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