Structure of PDB 8q5i Chain z Binding Site BS02

Receptor Information

>8q5i Chain z (length=179) Species: 5476 (Candida albicans)

ANLRTQKRLAASVIGVGKRKVWLDPNETTEIANANSRSAIRKLYKNGTIV
KKPETVHSRSRARALKESKRAGRHMGYGKRKGTKDARMPSQVLWMRRLRV
LRKLLAKYRDAGKIDKHLYHNLYKAAKGNTFKHKRSLVEHIIAAKAEALR
EKALKEEAEARRVRNRAARERRQQRLAEK

Ligand information

>8q5i Chain A (length=1558)

uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguauacuuggauaaccgugguaau
ucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguauu
uauuagagaugauucauaauaacuuuucgaaucgcauggccuugugcugg
cgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauagu
ggccuaccaugguuucaacggguaacggggaauaaggguucgauuccgga
gagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgc
aaauuacccaaucccgacacggggagguagugacaauaaauaacgauaca
gguuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauug
gagggcaagucuggugccagcagccgcgguaauuccagcuccaaaagcgu
auauuaaaguuguugcaguuaaaaagcucguaguugaaccuugggcuugg
cugcagccgagccuuuuuuacuuugaaaaaauuagaguguucaaagcagg
ccuuugcucgaauauauuagcauggaauaauagaauaggacguuauaucg
uaaugauuaauagggacggucggggguaucaguauucaguugucagaggu
gaaauucuuggauuuacugaagacuaacuacugcgaaagcauuuaccaag
gacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucaga
uaccgucguagucuuaaccauaaacuaugccgacuagggaucgguuguug
uucugacgcaaucggcaccuuacgagaaaucaaagucuuuggguucuggg
gggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcacc
accaggaguggagccugcggcuuaauuugacucaacacggggaaacucac
cagguccagacacugagagcugugggugguggugcauggccguucuuagu
ugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaacc
uacuaaauagugccacuucuuagagggacuaucgauuucaagucgaugga
aguuugaggcaauaacaggucugugaugcccuuagacguucugggccgca
cgcgcgcuacacugacggagccagcgaguauaagccuuggccgagagguc
ugggaaaucuugugaaacuccgucgugcuggggauagagcauuguaauug
uugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguu
gauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauuga
auggcuuagugaggccuccggauuggcgagaagcuggucaaacuugguca
uuuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcgga
aggaucau

...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<....<<..........>>...>>.>>......<<..
......<<<..<<..<<....<<<.........<<.....<..<<.....
..>>..>......>>........<<<<<..<<....>>..>>>>><...<
<<<<<...........>>>>>>.....>...<<<<..<<<.....>>>.>
>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.....
..>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>
>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>....
.....<<<....<<<<...>>>>..>>>..>....>.>.....<<<<...
<..>...>>>>......<<..<...........>..>>.........<<<
<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>
>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<<<<<
<<..>>>>>>>>>>...<<<<<.<<.......<<...<.......>..<<
<....>>>....>>......>>.>>..>>>.........<<<..<..>>>
>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<..
....>>>......>.>>>>>>..>>.......<<....>>...>>>>...
>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<....
.>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<..
<<..>>.>>>>>>>>..>>>...<<..))>>...>>.....>>>.>>>.<
<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..
<<.<<<<<<..<<<.<<<<.<......<<........>>..........<
<<<<.<....<<<........>>>...<<.<<<..<<.<<<<<<....<<
<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<
..<<<<..<<<<.>>>>..>>>>.>>....<<<<<<.....>>>>>>...
....>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>..
>>>>.>>>.....<<<<<<<......<<......<<<.<<<<....>>>>
.>>>....>>.......>>>>>>>...........<<<<<<.........
.>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>
......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<
<<<<<<.<<<..<<<<..<...<<<.>>>...>..>>>>..>>>.>>>>>
>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>
>.......

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8q5i Structural characterization of cephaeline binding to the eukaryotic ribosome using Cryo-Electron Microscopy
• Resolution: 2.45 Å
• Binding residue (original residue number in PDB): R162 R163 R165 N166 R170 R172 R173 R176
• Binding residue (residue number reindexed from 1): R161 R162 R164 N165 R169 R171 R172 R175

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0009986 cell surface
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8q5i, PDBe:8q5i, PDBj:8q5i
• PDBsum: 8q5i
• UniProt: A0A1D8PK40|RL19A_CANAL Large ribosomal subunit protein eL19 (Gene Name=RPL19A)