Structure of PDB 6zxf Chain z Binding Site BS02

Receptor Information
>6zxf Chain z (length=373) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TDSVINKVTEKSRQKEADMYRIKDKADRATVEQVLDPRTRMILFKMLTRG
IITEINGCISTGKEANVYHASTANGESRAIKIYKTSILVFKDRDKYVSGE
FRFRHGYCKGNPRKMVKTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVM
SFIGKDDMPAPLLKNVQLSESKARELYLQVIQYMRRMYQDARLVHADLSE
FNMLYHGGGVYIIDVSQSVEHDHPHALEFLRKDCANVNDFFMRHSVAVMT
VRELFEFVTDPSITHENMDAYLSKAMEIASQRTKSSQDHVDEEVFKRAYI
PRTLNEVKNYERDMDIIMKLQDNILYQTVTGLKKDLSGVQKVPAKKERKK
MVKEAQREKRKNKIPKHVKKRKE
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6zxf Chain z Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6zxf Structural basis for the final steps of human 40S ribosome maturation.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		E191 D341
Binding residue
(residue number reindexed from 1)		E64 D214
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
3.6.3.-
Gene Ontology
Molecular Function
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0044024 histone H2AS1 kinase activity
GO:0046872 metal ion binding
GO:0106310 protein serine kinase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0016310 phosphorylation
GO:0030490 maturation of SSU-rRNA
GO:0042254 ribosome biogenesis
GO:0042274 ribosomal small subunit biogenesis
GO:2000234 positive regulation of rRNA processing
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030688 preribosome, small subunit precursor
GO:0034708 methyltransferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6zxf, PDBe:6zxf, PDBj:6zxf
PDBsum6zxf
PubMed33208940
UniProtQ9BRS2|RIOK1_HUMAN Serine/threonine-protein kinase RIO1 (Gene Name=RIOK1)

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