Structure of PDB 6q8y Chain z Binding Site BS02

Receptor Information

>6q8y Chain z (length=874) Species: 4932 (Saccharomyces cerevisiae)

IPKFFRYISERWPMILQLIEGTQIPEFDNLYLDMNSILHNCTHGNDDDVT
KRLTEEEVFAKICTYIDHLFQTIKPKKIFYMAIDGVAPRAKMNQQRARRF
RTAMDAEKALKKAIENGDEIPKGEPFDSNSITPGTEFMAKLTKNLQYFIH
DKISNDSKWREVQIIFSGHEVPGEGEHKIMNFIRHLKSQKDFNQNTRHCI
YGLDADLIMLGLSTHGPHFALLREEVTFGRRNSEKKSLEHQNFYLLHLSL
LREYMELEFKEIADEMQFEYNFERILDDFILVMFVIGNDFLPNLPDLHLN
KGAFPVLLQTFKEALLHTDGYINEHGKINLKRLGVWLNYLSQFELLNFEK
DDIDVEWFNLVKQQKKLIGSIKPWLMEQLQEKLSPDLPDEEIPTLELPKD
LDMKDHLEFLKEFAFDLGLFITHSKSKGSYSLKMDLDSIEEEFQNRVNSI
RKTIKKYQNATEKTIYNERFERWKHEYYHDKLKFTTDSEEKVRDLAKDYV
EGLQWVLYYYYRGCPSWSWYYPHHYAPRISDLAKGLDQDIEFDLSKPFTP
FQQLMAVLPERSKNLIPPAFRPLMYDEQSPIHDFYPAEVQLDKNGKTADW
EAVVLISFVDEKRLIEAMQPYLRKLSPEEKTRNQFGKDLIYSFNPQVDNL
YKSPLGGIFSDIEHNHCVEKEYISEIRYGLLPNAKLGAEMLAGFPTLLSL
PFTSSLEYNETMVFQQPSKQQSMVLQITDIYKTNNVTLEDFSKRHLNKVI
YTRWPYLRESKLVSLTDGKTIYEYQESNDKKKFGFITKPAETQDKKLFNS
LKNSMLRMYAKQKAVKIGPMEAIATVFPVTGLVRDSDGGYIKTFSPTPDY
YPLQLVVESVVNEDERYKERGPIP

Ligand information

>6q8y Chain l (length=17)

aauccuggauggaacga

.................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6q8y Structure of the 80S ribosome-Xrn1 nuclease complex.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): I3 K5 H41 R100 E178 L205 D206 D208 R233 T635 W638
• Binding residue (residue number reindexed from 1): I1 K3 H39 R98 E176 L203 D204 D206 R231 T597 W600

Enzymatic activity

• Enzyme Commision number: 3.1.13.-

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0004527 exonuclease activity

External links

• PDB: RCSB:6q8y, PDBe:6q8y, PDBj:6q8y
• PDBsum: 6q8y
• PubMed: 30911188
• UniProt: P22147|XRN1_YEAST 5'-3' exoribonuclease 1 (Gene Name=XRN1)