BioLiP

Receptor Information

>5l3p Chain z (length=545) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EFDPEKWIASLGITSQKSCECLAETWAYCLQQTQGHPDASLLLWRGVEMV
EILSTLSMDIDTLRAALLFPLADANVVSEDVLRESVGKSVVNLIHGVRDM
AAIRQDNVRRMLLAMVDDFRCVVIKLAERIAHLREDERVLAAKECTNIYA
PLANRLGIGQLKWELEDYCFRYLHPTEYKRIAKLLHERRLDREHYIEEFV
GHLRAEMKAEGVKAEVYGRPKHIYSIWRKMQKKNLAFDELFDVRAVRIVA
ERLQDCYAALGIVHTHYRHLPDEFDDYVANPKPNGYQSIHTVVLGPGGKT
VEIQIRTKQMHEDAELGDRIAWLRKLVFDDRVYVFTPKGDVVDLPAGSTP
LDFAYHIHSDVGHRCIGAKIGGRIVPFTYQLQMGDQIEIITQAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAGYSLVVRVVANDRSGLLRDITTILANEKVNVL
GVASRSDTKQQLATIDMTIEIYNLQVLGRVLGKLNQVPDVIDARR

>5l3p Chain y (length=73) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gcugauauagcucaguugguagagcgcacccuuggugagggugaggucgg
caguucgaaucugccuaucagca

.<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<
<<.........>>>>>>>>>>..

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5l3p The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis.
Resolution	3.7 Å
Binding residue (original residue number in PDB)	X514 X526 X535 X537 X538 X541
Binding residue (residue number reindexed from 1)	X420 X432 X441 X443 X444 X447

Enzyme Commision number

2.7.6.5: GTP diphosphokinase.

	Biological Process
GO:0015969	guanosine tetraphosphate metabolic process

PDB	RCSB:5l3p, PDBe:5l3p, PDBj:5l3p
PDBsum	5l3p
PubMed	27226493
UniProt	P0AG20\|RELA_ECOLI GTP pyrophosphokinase (Gene Name=relA)

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Structure of PDB 5l3p Chain z Binding Site BS02