Structure of PDB 8pj2 Chain y Binding Site BS02

Receptor Information
>8pj2 Chain y (length=656) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VVRSAKDKRFEELTNLIRTIRNAMKIRDVTKCLEEFELLGKAYGKAKSIV
DKEGVPRFYIRILADLEDYLNELWEDKEGKKKMNKNNAKALSTLRQKIRK
YNRDFESHITSYKMFAKGTEITHAVVIKKLNEILQARGKKGTDRAAQIEL
LQLLVQIAAENNLGEGVIVKIKFNIIASLYDYNPNLATYMKPEMWGKCLD
CINELMDILFANPNIFVGENILEESENLHNADQPLRVRGCILTLVERMDE
EFTKIMQNTDPHSQEYVEHLKDEAQVCAIIERVQRYLEEKGTTEEVCRIY
LLRILHTYYKFDYKAHQRQNEGEDSAVLMERLCKYIYAKDRTDRIRTCAI
LCHIYHHALHSRWYQARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGIC
AFRQGLTKDAHNALLDIQSSGRAKELLGQGLLLRSLQERNQEQEKVERRR
QVPFHLHINLELLECVYLVSAMLLEIPYMAAHESDARRRMISKQFHHQLR
VGERQPLLGPPESMREHVVAASKAMKMGDWKTCHSFIINEKMNGKVWDLF
PEADKVRTMLVRKIQEESLRTYLFTYSSVYDSISMETLSDMFELDLPTVH
SIISKMIINEELMASLDQPTQTVVMHRTEPTAQQNLALQLAEKLGSLVEN
NERVFD
Ligand information
>8pj2 Chain A (length=1754) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucugaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgcuccuacuuggauaacugug
guaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggg
gggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucg
cacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacu
uucgaugguagucgccgugccuaccauggugaccacgggugacggggaau
caggguucgauuccggagagggagccugagaaacggcuaccacauccaag
gaaggcagcaggcgcgcaaauuacccacucccgacccggggagguaguga
cgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagu
ccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugcca
gcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcagu
uaaaaagcucguaguuggaucuugggagcgggcgggcgguccgccgcgag
gcgagccaccgcccguccccgccccucucggcggcccgaagcguuuacuu
ugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcag
cuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaac
ugaggccaugauuaagagggacggccgggggcauucguauugcgccgcua
gaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuug
ccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacga
ucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcgg
cggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuu
uggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugac
ggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacg
ggaaaccucacccggcccggacacggacaggauugacagauugauagcuc
uuucucgauuccgugggugguggugcauggccguucuuaguugguggagc
gauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacua
guuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaa
guggcguucagccacccgagauugagcaauaacaggucugugaugcccuu
agauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccu
acccuacgccggcaggcgcggguaacccguugaaccccauucgugauggg
gaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugc
gggucauaagcuugcguugauuaagucccugcccuuuguacacaccgccc
gucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgc
cgggggcccuggcggagcgcugagaagacggucgaacuugacuaucuaga
ggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggauc
auua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<.............<<.....<<.<<
<.....>>>.>>......>>.........<<<<...<<<<........>>
>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<
<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<
....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<
....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....
>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>..
.>>.>.....<..<...<<..<<....>>..>>.....>...>.....<<
..<...........>..>>.........<<<<<((......<<<<.....
<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<(
(.....<.<<...<<<.<<........<<<<<<<<<<<<<.<<<<....>
>>>....>>>>>>>>..>>>>>..<<.............>>...<<<<<<
.<.......<<...<.......>.<<<<.......>>>>...>>......
>.>>>..>>>........<.<<.<<<<<..................>>.>
>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...
<<<......>>>......>>>>>>>>..>>.......<<....>>...>>
>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.
<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<
<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>...
..>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<
<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>
..........<<<<<.<....<<<<<<.......<<.<<<........>>
>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<..
..>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<
<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....
<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.
....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.....
..<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.
....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<
<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<
<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.....
..................>>>>>...>>.>>>>..>>>.>>>>>>>>...
>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>.....
....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8pj2 Structural basis for translational control by the human 48S initiation complex from codon scanning toward subunit joining
Resolution3.4 Å
Binding residue
(original residue number in PDB)
V48 V49 R50 S51 K55 E84 K88 K92 W121 M130 N131 K132 N133 A135 K136 S139 T140 Q143 K144 R146 K147 R150 K342 K343
Binding residue
(residue number reindexed from 1)
V1 V2 R3 S4 K8 E37 K41 K45 W74 M83 N84 K85 N86 A88 K89 S92 T93 Q96 K97 R99 K100 R103 K139 K140
External links
PDB RCSB:8pj2, PDBe:8pj2, PDBj:8pj2
PDBsum8pj2
PubMed
UniProtQ99613|EIF3C_HUMAN Eukaryotic translation initiation factor 3 subunit C (Gene Name=EIF3C)

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