Structure of PDB 6zxe Chain y Binding Site BS02

Receptor Information

>6zxe Chain y (length=325) Species: 9606 (Homo sapiens)

VVADAGAFLRHAALQDIGKNIYTIREVVTEIRDKATRRRLAVLPYELRFK
EPLPEYVRLVTEFSKKTGDYPSLSATDIQVLALTYQLEAEFVGVSHLKQE
PQKVKVSSSIQHPETPLHISGFHLPGGWITPSNIKQIQQELEVRVGCLTT
DFAMQNVLLQMGLHVLAVNGMLIREARSYILRCHGCFKTTSDMSRVFCSH
CGNKTLKKVSVTVSDDGTLHMHFSRNPKVLNPRGLRYSLPTPKGGKYAIN
PHLTEDQRFPQLRLSQKARQKTNVFAPDYIAGVSPFVENDISSRSATLQV
RDSTLGAGRRRLNPNASRKKFVKKR

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 6zxe Chain y Residue 500

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zxe Structural basis for the final steps of human 40S ribosome maturation.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): C270 C285
• Binding residue (residue number reindexed from 1): C183 C198
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Gene Ontology

Molecular Function

• GO:0004519 endonuclease activity
• GO:0004521 RNA endonuclease activity
• GO:0005515 protein binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006364 rRNA processing
• GO:0007601 visual perception
• GO:0030490 maturation of SSU-rRNA
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005829 cytosol
• GO:0030688 preribosome, small subunit precursor

External links

• PDB: RCSB:6zxe, PDBe:6zxe, PDBj:6zxe
• PDBsum: 6zxe
• PubMed: 33208940
• UniProt: Q9ULX3|NOB1_HUMAN RNA-binding protein NOB1 (Gene Name=NOB1)