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Receptor Information

>7syv Chain x (length=627) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPVICVLGHVDTG
KTKILDKLRHTHVQDGEAGGITQQIGATNVPLEAINEQTKMIKNFDRENV
RIPGMLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINL
LKSKKCPFIVALNKIDRLYDWKKSPDSDVAATLKKQKKNTKDEFEERAKA
IIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVELTQ
TMLSKRLAHCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGV
EGPIVTQIRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLA
GLPLLVAYKEDEIPVLKDELIHELKQTLNAIKLEEKGVYVQASTLGSLEA
LLEFLKTSEVPYAGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIER
DAQEMADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIAVFPCK
MKILPQYIFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEV
NHKQVDVAKKGQEVCVKIEPIPGESPKMFGRHFEATDILVSKISRQSIDA
LKDWFRDEMQKSDWQLIVELKKVFEII

>7syv Chain i (length=75) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgau
ggaucgaaaccauccucugcuacca

.<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<
<<.......>>>>>>>>>>>.....

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7syv Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.
Resolution	3.9 Å
Binding residue (original residue number in PDB)	F1100 R1103 E1140 H1143 S1166 R1172
Binding residue (residue number reindexed from 1)	F509 R512 E549 H552 S575 R581

Enzyme Commision number

	Molecular Function
GO:0003924	GTPase activity
GO:0005525	GTP binding

PDB	RCSB:7syv, PDBe:7syv, PDBj:7syv
PDBsum	7syv
PubMed	35822879
UniProt	G1TRL5

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Structure of PDB 7syv Chain x Binding Site BS02