Structure of PDB 8cvm Chain w Binding Site BS02

Receptor Information
>8cvm Chain w (length=60) Species: 1747 (Cutibacterium acnes) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AAVCDICAKRPGFGHNVPWSKKKTNRRWSPNIQRVRVVENGTHKRMNVCT
SCLKAGRVSR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8cvm Chain w Residue 101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8cvm Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism.
Resolution2.66 Å
Binding residue
(original residue number in PDB)		C5 I7 C8 C50 C53
Binding residue
(residue number reindexed from 1)		C4 I6 C7 C49 C52
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Biological Process
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Cellular Component
External links
PDB RCSB:8cvm, PDBe:8cvm, PDBj:8cvm
PDBsum8cvm
PubMed36864821
UniProtA0A2B7I7B7

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