Structure of PDB 8i0t Chain v Binding Site BS02

Receptor Information
>8i0t Chain v (length=173) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GGKTGSGGVASSSESNRDRRERLRQLALETIDINKDPYFMKNHLGSYECK
LCLTLHNNEGSYLAHTQGKKHQTNLARRAAKEAKEAPVEVKKFVKIGRPG
YKVTKQLFQIDYPEIAEGIMPRHRFMSAYEQRIEPPDRRWQYLLMAAEPY
ETIAFKVPFWTHWNRETKQFFLQ
Ligand information
>8i0t Chain H (length=167) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aucgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuauc
aguuuaauaucugauguccucucgaggacggauuuuuggagcagggagau
ggaauaggagcuugcuccguccacuccacgcaucgaccugguauugcagu
accuccaggaacggugc
................................................<<
<<........>>>>.<<<<<<..>>>>>>...............<<<<.<
<<<...<<<<....>>>>.>>>>>>>>..<<<<<<.<<<<<.........
....>>>>>..>>>>>>
Receptor-Ligand Complex Structure
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PDB8i0t Molecular basis for the activation of human spliceosome
Resolution3.0 Å
Binding residue
(original residue number in PDB)		T61 L62 K76 K77
Binding residue
(residue number reindexed from 1)		T54 L55 K69 K70
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000389 mRNA 3'-splice site recognition
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0010976 positive regulation of neuron projection development
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0016607 nuclear speck
GO:0071004 U2-type prespliceosome
GO:0071005 U2-type precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8i0t, PDBe:8i0t, PDBj:8i0t
PDBsum8i0t
PubMed39068178
UniProtQ15428|SF3A2_HUMAN Splicing factor 3A subunit 2 (Gene Name=SF3A2)

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