Structure of PDB 7nfx Chain v Binding Site BS02

Receptor Information
>7nfx Chain v (length=186) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RAVLLVGLCDSGKTLLFVRLLTGLYRDTQTSITDSCAVYRVNNNRGNSLT
LIDLPGHESLRLQFLERFKSSARAIVFVVDSAAFQREVKDVAEFLYQVLI
DSMGLKNTPSFLIACNKQDIAMAKSAKLIQQQLEKELNTLRVTGKEFEFS
QLPLKVEFLECSAKGGRGDVGSADIQDLEKWLAKIA
Ligand information
Ligand IDGTP
InChIInChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyXKMLYUALXHKNFT-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.370NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.370NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
OpenEye OEToolkits 1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
FormulaC10 H16 N5 O14 P3
NameGUANOSINE-5'-TRIPHOSPHATE
ChEMBLCHEMBL1233147
DrugBankDB04137
ZINCZINC000060094177
PDB chain7nfx Chain v Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7nfx Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		C73 D74 G76 K77 T78 L79 T92 S95 G120 N180 K181 D183 S247 A248 K249
Binding residue
(residue number reindexed from 1)		C9 D10 G12 K13 T14 L15 T28 S31 G56 N116 K117 D119 S162 A163 K164
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
GO:0045047 protein targeting to ER
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005785 signal recognition particle receptor complex
GO:0005789 endoplasmic reticulum membrane
GO:0005881 cytoplasmic microtubule
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7nfx, PDBe:7nfx, PDBj:7nfx
PDBsum7nfx
PubMed34020957
UniProtQ9Y5M8|SRPRB_HUMAN Signal recognition particle receptor subunit beta (Gene Name=SRPRB)

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