Structure of PDB 8ceu Chain u Binding Site BS02

Receptor Information

>8ceu Chain u (length=93) Species: 679895 (Escherichia coli BW25113)

FTINAEVRKEQGKGASRRLRAANKFPAIIYGGKEAPLAIELDHDKVMNMQ
AKAEFYSEVLTIVVDGKEIKVKAQDVQRHPYKPKLQHIDFVRA

Ligand information

>8ceu Chain b (length=119)

ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacuca
gaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgag
aguagggaacugccaggca

<<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>
>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>...
....>>...>>>>>>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ceu Structural conservation of antibiotic interaction with ribosomes.
• Resolution: 1.83 Å
• Binding residue (original residue number in PDB): R9 Q12 G13 K14 S17 R18 R19 R21 I29 Y31 P37 Q75 Q78 H88 D90
• Binding residue (residue number reindexed from 1): R8 Q11 G12 K13 S16 R17 R18 R20 I28 Y30 P36 Q74 Q77 H87 D89

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0008097 5S rRNA binding
• GO:0019843 rRNA binding

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0009314 response to radiation
• GO:0017148 negative regulation of translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8ceu, PDBe:8ceu, PDBj:8ceu
• PDBsum: 8ceu
• PubMed: 37550453
• UniProt: P68919|RL25_ECOLI Large ribosomal subunit protein bL25 (Gene Name=rplY)