Structure of PDB 7abh Chain u Binding Site BS02

Receptor Information
>7abh Chain u (length=932) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EYKKHRRTMIISAETPRTDRGGDSIGETPTPGASKRKERNRPLSDEELDA
MFPEGYKVLPPPAGYVPIRTPARKLTATPTPLGGMKSVNDQPSGNLPFLK
PDDIQYFDKLLVDVDESEEQKERKIMKLLLKIKNGTPPMRKAALRQITDK
AREFGAGPLFNQILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVRPYVH
KILVVIEPLLIDEDYYARVEGREIISNLAKAAGLATMISTMRPDIDNMDE
YVRNTTARAFAVVASALGIPSLLPFLKAVCKSKKSWQARHTGIKIVQQIA
ILMGCAILPHLRSLVEIIEHGLVDEQQKVRTISALAIAALAEAATPYGIE
SFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLI
LIREFQSPDEEMKKIVLKVVKQCCGTDGVEANYIKTEILPPFFKHFWQHR
MALDRRNYRQLVDTTVELANKVGAAEIISRIVDDLKDEAEQYRKMVMETI
EKIMGNLGAADIDHKLEEQLIDGILYAFQEQTTEDSVMLNGFGTVVNALG
KRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMG
HLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRLTP
ILKNRHEKVQENCIDLVGRIADRGAEYVSAREWMRICFELLELLKAHKKA
IRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQNRVCTTVAIAIVAET
CSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPL
LEDALMDRDLVHRQTASAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVFET
SPHVIQAVMGALEGLRVAIGPCRMLQYCLQGLFHPARKVRDVYWKIYNSI
YIGSQDALIAHYPRIYNDDKNTYIRYELDYIL
Ligand information
>7abh Chain 2 (length=37) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aaguguaguaucuguucuuaucaguuuaauaucugau
...................<<<<<........>>>>>
Receptor-Ligand Complex Structure
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PDB7abh Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation.
Resolution4.5 Å
Binding residue
(original residue number in PDB)		P1224 P1257 A1258 R1259
Binding residue
(residue number reindexed from 1)		P852 P885 A886 R887
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:1990935 splicing factor binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006338 chromatin remodeling
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045943 positive regulation of transcription by RNA polymerase I
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045945 positive regulation of transcription by RNA polymerase III
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0005689 U12-type spliceosomal complex
GO:0005730 nucleolus
GO:0016607 nuclear speck
GO:0034693 U11/U12 snRNP
GO:0071004 U2-type prespliceosome
GO:0071005 U2-type precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome
GO:0110016 B-WICH complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7abh, PDBe:7abh, PDBj:7abh
PDBsum7abh
PubMed33243851
UniProtO75533|SF3B1_HUMAN Splicing factor 3B subunit 1 (Gene Name=SF3B1)

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