Structure of PDB 8bpo Chain t2 Binding Site BS02

Receptor Information
>8bpo Chain t2 (length=418) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ILQKLQELVDQLYSFRDCYFETHSVEDAGRKQQDVQKEMEKTLQQMEEVV
GSVQGKAQVLMLTGKALNAEELLSKAVKLEPELVEAWNQLGEVYWKKGDV
AAAHTCFSGALTHCRNKVSLQNLSMVLRQLRTDTEDEHSHHVMDSVRQAK
LAVQMDVHDGRSWYILGNSYLSLYFSTGQNPKISQQALSAYAQAEKVDRK
ASSNPDLHLNRATLHKYEESYGEALEGFSRAAALDPAWPEPRQREQQLLE
FLDRLTSLLESKGKVKTKKLQSMLGSLRPAHLGPCSDGHYQSASGQKVTL
ELKPLSTLQPGVNSGAVILGKVVFSLTTEEKVPFTFGLVDSDGPCYAVMV
YNIVQSWGVLIGDSVAIPEPNLRLHRIQHKGKDYSFSSVRVETPLLLVVN
GKPQGSSSQAVATVASRP
Ligand information
Receptor-Ligand Complex Structure
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PDB8bpo Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		W114 F194 D225 N229 R263 E349 V351 A429 A431 T432 V433 A434 R436
Binding residue
(residue number reindexed from 1)		W95 F175 D206 N210 R244 E330 V332 A410 A412 T413 V414 A415 R417
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0043022 ribosome binding
Biological Process
GO:0006281 DNA repair
GO:0006974 DNA damage response
GO:0009267 cellular response to starvation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0061014 positive regulation of mRNA catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0031410 cytoplasmic vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8bpo, PDBe:8bpo, PDBj:8bpo
PDBsum8bpo
PubMed37295431
UniProtQ8N0Z6|TTC5_HUMAN Tetratricopeptide repeat protein 5 (Gene Name=TTC5)

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