Structure of PDB 8gzu Chain sb Binding Site BS02

Receptor Information
>8gzu Chain sb (length=279) Species: 312017 (Tetrahymena thermophila SB210) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SICLESISGTIKGLQKANYVVEHNPNLTSEEKKHLKQFLVYRYNPADPHD
QPKYVSYWCDIKKFPPMFLDAILYIKNELDPTLSIRRSCREGICGSCAVN
CDGLHTLACISGFNRDLSKPTIITPLGHMFILKDLVVDMTNFYAQYKMIE
PYLKRKTPKPDANKEYPQSPEQRALLDGLYECVLCAACSTSCPSYWWHPD
RYLGPAILQQAYRWIVDSRDEYTQERIERIAEDVRLDDCQQIGMCSFTCP
KGLNPQLSLKNLMDMVKDFRQKRIEQEVL
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain8gzu Chain sb Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8gzu Structures of Tetrahymena thermophila respiratory megacomplexes on the tubular mitochondrial cristae.
Resolution4.18 Å
Binding residue
(original residue number in PDB)		C215 V216 L217 C218 A219 C221 A239 C282
Binding residue
(residue number reindexed from 1)		C182 V183 L184 C185 A186 C188 A206 C249
Annotation score1
Enzymatic activity
Enzyme Commision number 1.3.5.1: succinate dehydrogenase.
Gene Ontology
Molecular Function
GO:0008177 succinate dehydrogenase (quinone) activity
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
GO:0051538 3 iron, 4 sulfur cluster binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0009060 aerobic respiration
GO:0022904 respiratory electron transport chain
Cellular Component
GO:0005743 mitochondrial inner membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8gzu, PDBe:8gzu, PDBj:8gzu
PDBsum8gzu
PubMed37248254
UniProtI7M403

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