Structure of PDB 8am9 Chain r Binding Site BS02

Receptor Information

>8am9 Chain r (length=110) Species: 679895 (Escherichia coli BW25113)

METIAKHRHARSSAQKVRLVADLIRGKKVSQALDILTYTNKKAAVLVKKV
LESAIANAEHNDGADIDDLKVTKIFVDEGPSMKRIMPRAKGRADRILKRT
SHITVVVSDR

Ligand information

>8am9 Chain A (length=19) Species: 7227 (Drosophila melanogaster)

GKPRPYSPRPTSHPRPIRV

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8am9 Structural basis for translation inhibition by the glycosylated drosocin peptide.
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): K90 G91 R92 A93
• Binding residue (residue number reindexed from 1): K90 G91 R92 A93

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0019843 rRNA binding
• GO:0070180 large ribosomal subunit rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0042255 ribosome assembly
• GO:0042256 cytosolic ribosome assembly
• GO:0046677 response to antibiotic
• GO:1902626 assembly of large subunit precursor of preribosome

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8am9, PDBe:8am9, PDBj:8am9
• PDBsum: 8am9
• PubMed: 36997646
• UniProt: P61175|RL22_ECOLI Large ribosomal subunit protein uL22 (Gene Name=rplV)