Structure of PDB 8wan Chain p Binding Site BS02

Receptor Information
>8wan Chain p (length=1149) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPPI
DLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARL
RNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNG
LTDRDLCELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKY
AYTGECRSCLENSSRPTSTIWVSMLARGGQGAKKSAIGQRIVATLPYIKQ
EVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEMVKPSLDEAFVIQEQN
VALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETKKAYFL
GYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEV
RIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAG
VSQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETP
EGHAVGLVKNLALMAYISVGSQPSPILEFLEEWSMENLEEISPAAIADAT
KIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSEVSMIRDIREREIRIY
TDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASGVVEYI
DTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPD
HNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSME
YLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYK
EQESKKGFDQEEVFEKPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDV
IIGKTVTLPENETKRDCSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRS
VRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSR
MTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGYHLRGN
EVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPM
EGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIM
AIANTRTHTYECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV
Ligand information
>8wan Chain Y (length=73) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gtaggcacgtctgctcggctcgaagtagatgaagccaatgaagacacaac
cacccccttttataggcgccctt
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8wan Structural Visualization of de novo Transcription Initiation.
Resolution6.07 Å
Binding residue
(original residue number in PDB)		N188 S190 Y446 T450 T746 L747 R812 G1077 R1078 R1085
Binding residue
(residue number reindexed from 1)		N173 S175 Y431 T435 T731 L732 R797 G1052 R1053 R1060
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005654 nucleoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8wan, PDBe:8wan, PDBj:8wan
PDBsum8wan
PubMed38127763
UniProtA0A4X1TVZ5

[Back to BioLiP]