Structure of PDB 6ole Chain p Binding Site BS02

Receptor Information
>6ole Chain p (length=105) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGKRRYDRKQSGYGGQ
TKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKG
QVIQF
Ligand information
>6ole Chain v (length=76) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugcccgguagccccgaagguagagcaggggauuccgaauccccguguccu
ugguucgauuccgaguccgggcacca
..<<<<<..<<............>>.<<<<<<.....>>>>>>......<
<<.........>.>>.>>>>>.....
Receptor-Ligand Complex Structure
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PDB6ole Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		G37 K38 Y41 I55 F56
Binding residue
(residue number reindexed from 1)		G36 K37 Y40 I54 F55
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005886 plasma membrane
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:1990904 ribonucleoprotein complex

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Biological Process
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Cellular Component
External links
PDB RCSB:6ole, PDBe:6ole, PDBj:6ole
PDBsum6ole
PubMed31160784
UniProtP83881|RL36A_HUMAN Large ribosomal subunit protein eL42 (Gene Name=RPL36A)

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