Structure of PDB 8pw7 Chain o Binding Site BS02

Receptor Information
>8pw7 Chain o (length=227) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAYPFQLGLQDATSPIMEELMNFHDHTLMIVFLISSLVLYIISLMLTTKL
THTSTMDAQEVETIWTILPAVILIMIALPSLRILYMMDEINNPVLTVKTM
GHQWYWSYEYTDYEDLCFDSYMIPTNDLKPGELRLLEVDNRVVLPMELPI
RMLISSEDVLHSWAVPSLGLKTDAIPGRLNQATVTSNRPGLFYGQCSEIC
GSNHSFMPIVLEMVPLKYFENWSASMI
Ligand information
Ligand IDCUA
InChIInChI=1S/2Cu
InChIKeyALKZAGKDWUSJED-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Cu][Cu]
FormulaCu2
NameDINUCLEAR COPPER ION
ChEMBL
DrugBank
ZINC
PDB chain8pw7 Chain o Residue 303 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8pw7 SCAF1 drives the compositional diversity of mammalian respirasomes.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		H161 C196 C200 H204 M207
Binding residue
(residue number reindexed from 1)		H161 C196 C200 H204 M207
Annotation score1
Enzymatic activity
Enzyme Commision number 7.1.1.9: cytochrome-c oxidase.
Gene Ontology
Molecular Function
GO:0004129 cytochrome-c oxidase activity
GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0001666 response to hypoxia
GO:0007595 lactation
GO:0022900 electron transport chain
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0031966 mitochondrial membrane
GO:0045277 respiratory chain complex IV

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8pw7, PDBe:8pw7, PDBj:8pw7
PDBsum8pw7
PubMed38575788
UniProtP00405|COX2_MOUSE Cytochrome c oxidase subunit 2 (Gene Name=Mtco2)

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